There are now no people at the Manston migrant processing centre, Sky News understands.
The Home Office site in Kent, where thousands of migrants arriving in small boats have been taken since it opened in January, currently has zero people in it.
In recent weeks Manston has been at the centre of controversy as it is designed to hold up to 1,600 people for no more than 24 hours.
But earlier this month there were about 4,000 people in the centre, some who said they had been there for much longer than they should have been.
Migrants said they were sleeping on cardboard and unrest was spreading due to the conditions.
Concerns over infectious diseases were raised, with reports of diphtheria.
Three days ago, a man staying at the centre became unwell and died after arriving in the UK by small boat the weekend before.
There is “no evidence at this stage” to suggest the death was “caused by an infectious disease”, the Home Office said.
The Home Office said there will be no detailed comment until a post-mortem examination has been carried out.